Summer Reading List: Q2 2026 Publications from our Innovation Ecosystem
July 8, 2026 Amy Easton
An ALS subtype–specific SNRNP70 exon-8 splicing alteration is associated with ubiquitin–proteasome pathway signatures. Tadashi Nakaya, Gene Reports, Volume 43, 2026, 102497, ISSN 2452-0144, https://doi.org/10.1016/j.genrep.2026.102497. (https://www.sciencedirect.com/science/article/pii/S2452014426000725)
Selective, genetically induced increase in synaptic vesicle priming. Aldahabi M, Balint F, Lorincz A, Lipstein N, Brose N, Nusser Z. Sci Adv. 2026 Apr 10;12(15):eaee6848. doi: 10.1126/sciadv.aee6848. Epub 2026 Apr 8. PMID: 41950325; PMCID: PMC13060592. Genetic contributions to mitochondrial dysfunction in amyotrophic lateral sclerosis etiology. Russell ND, Downie JM, Bromberg MB, Pulst SM, Jorde LB. HGG Adv. 2026 Apr 10:100614. doi: 10.1016/j.xhgg.2026.100614. Epub ahead of print. PMID: 41966055.
Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons. Vargas JNS, Brown AL, Sun K, […] Schiavo G. Sci Signal. 2026 Apr 14;19(933):eadx6752. doi: 10.1126/scisignal.adx6752. Epub 2026 Apr 14. PMID: 41980068.
Somatic mosaicism in ALS and FTD identifies focal mutations associated with widespread degeneration. Zhou, Z., Kim, J., Huang, A.Y. et al. Nat Genet (2026). https://doi.org/10.1038/s41588-026-02570-6
Protein misfolding enteropathy predicts and prognosticates neurodegenerative disease years before symptom onset. Tatiana Langerová, Emma MacVicar, Rollo Press, […] Jenna M. Gregory. Gastroenterology, 2026, ISSN 0016-5085, https://doi.org/10.1053/j.gastro.2026.04.003.
Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration. Copley KE, Mauna JC, Danielson HL, Chen Q, Ozguney B, Ngo M, […], Shorter J. Science. 2026 May 7;392(6798):eadv3301. doi: 10.1126/science.adv3301. Epub 2026 May 7. PMID: 42096556; PMCID: PMC13155378.
A Hierarchical Coarse-to-Fine Whisper Adaptation Framework for ALS Dysarthria Severity Estimation. S. Hreško, M. Hireš, J. Staš and P. Drotár. ICASSP 2026 – 2026 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP). Barcelona, Spain, 2026, pp. 21740-21742, doi: 10.1109/ICASSP55912.2026.11463559.
High-throughput screening approach identifies substrate-selective Hsp104 variants that counter amyloid seeding with diminished off-target effects. Ryan JJ, Miller KR, Puri A, Sprunger ML, […] Jackrel ME. Mol Cell. 2026 May 12:S1097-2765(26)00269-8. doi: 10.1016/j.molcel.2026.04.015. Epub ahead of print. PMID: 42127909.
CHI3L1 (YKL-40) and Chit-1 expressing glia in the white matter of ALS, FTLD and AD: correlations to pathology and disease duration. Tran CM, Reddy N, Thomas JK, Venugopal V, Bowser R. BMJ Neurology Open. 2026;8:e001225. https://doi.org/10.1136/bmjno-2025-001225
Integrated single-cell and spatial transcriptomic profiling in ALS uncovers peripheral-to-central immune infiltration and reprogramming. Zhang Z, van Olst L, Alessandrini F, […] Gate D. Nat Neurosci. 2026 May 14. doi: 10.1038/s41593-026-02300-5. Epub ahead of print. PMID: 42135512.
TDP-43: [GU]-ardian of the transcriptome. Sinha, I.R., Atkinson, A.L., Irwin, K.E. et al. Mol Neurodegeneration (2026). https://doi.org/10.1186/s13024-026-00944-2
BDNF insufficiency exacerbates ALS progression. Xu Y, He J, Wang S, […] Lu B. Cell Rep Med. 2026 Apr 20:102758. doi: 10.1016/j.xcrm.2026.102758. Epub ahead of print. PMID: 42013845.
Single-nucleus multiomic atlas of ALS primary motor cortex nominates neuroprotective WDR49-expressing astrocytes. Cooper-Knock, Johnathan; Bonsall, Sam; Kazu, Rodrigo; King, Marianne; Leung, Diana; Mahiddine, Farah; Highley, […] Snyder, Michael. Research Square. 2026 Jun 1. doi: 10.21203/rs.3.rs-4458231/v1.
Targeting MAPK-dependent pathways to modulate reactive astrocyte pathology in neurodegeneration. Pervaiz I, Blazier AS, Nyarko-Danquah I, Wesseling H, Ramos A, Woodworth L, […] Hagan N. Commun Biol. 2026 Jun 1. doi: 10.1038/s42003-026-10323-8. Epub ahead of print. PMID: 42225893.
Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction. Caiwei Guo et al.,,.Sci. Transl. Med.18,eaeb8517(2026).DOI:10.1126/scitranslmed.aeb8517
Arrayed dual-gRNA CRISPR screening platform for C9orf72 repeat expansion excision in patient iPSCs. Arogundade O, Lam K, Brown K … Molecular Therapy Advances, 2026; 34
Multiplexed temporal SWCNT biosensor combined with convolutional autoencoding identifies ALS-specific serum protein corona signatures. Riccardo Sirtori, Rodrigo Monroy Lopez, Huifang Li, Chang Liu, Nicholas Fisk, Daniel Roxbury, Claudia Fallini. medRxiv 2026.06.08.26354966; doi: https://doi.org/10.64898/2026.06.08.26354966
An emergent disease-associated motor neuron state precedes cell death in ALS. Gautier O, Blum JA, Nguyen TP, Cao S, Klemm S, Yamakawa M, […] Gitler AD. Cell. 2026 Jun 23:S0092-8674(26)00647-1. doi: 10.1016/j.cell.2026.05.047. Epub ahead of print. PMID: 42335888.
Value of synaptic proteins as biomarkers in amyotrophic lateral sclerosis. Frederik Hobin, Shreyasee Das, Charlotte Lambrechts, Charlotte De Rocker, Jonas Dubin, Fouke Ombelet, […] Philip Van Damme. Brain Communications, 2026;, fcag247, https://doi.org/10.1093/braincomms/fcag247
Isoform-specific steric zippers drive aberrant assembly and mislocalization of shortened TDP-43. Copley KE, Dykstra MM, Miller MR, Linsenmeier M, Lai L, Wang Y, Chang YW, Barmada SJ, Shorter J. Sci Adv. 2026 Jun 26;12(26):eady0256. doi: 10.1126/sciadv.ady0256. Epub 2026 Jun 24. PMID: 42341118; PMCID: PMC13292936.
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