The applications for use of most of our Core Resources are available on the relevant Target ALS webpage.

Applications for longitudinal biofluids and postmortem tissue require an experimental proposal and statement of scientific rationale. All applications are subject to a review process. The goal for both of these Core Resources is to provide access to human samples and tissue to everyone who requests them, although some alterations may be required to the proposed work.

To access the Target ALS Data Engine, a short description of planned work and a work email are required. Data added to the Engine after you have access will automatically be accessible to you.

Our induced pluripotent stem cell lines from ALS patients and controls are banked at NINDS. Following the link on our webpage to the NINDS portal will allow you to apply. The process is straightforward and all tools you need are available within the steps of the application.

Below are the direct links for ease of access:

Longitudinal Biofluids Core
Postmortem Tissue Core
Pluripotent Stem Cell Core
Target ALS Data Engine (includes data from all of the above Core facilities)
Reagents Core

To receive updates about what is available in our Core Resources, subscribe to our research-focused mailing list.

In short, yes. In some cases, industry researchers may need to pay a higher fee to access our Research Cores

No, Target ALS does not embargo publications. We do ask for authorship or acknowledgement on publications that use our Research Cores. The application process for the individual Core will clarify authorship requirements.

Currently, no. Our goal is to recruit separately for our Postmortem Tissue and Longitudinal Biofluids Cores, but individuals interested in contributing to both are able to do so. Individuals of this nature will be noted in the Data Engine. The Stem Cell Core does not contain iPSCs generated from the individuals who have contributed to the other two Cores.

In most cases, researchers are expected to pay the cost of shipping. Early stage researchers in the Target ALS ecosystem access all Target ALS Core Resources free of charge for the lifetime of their grant. There is a nominal fee to order the Target ALS iPSC lines and Target ALS Postmortem tissue. Access to the Target ALS Data Engine is free of charge.

No. As part of our mission to break down barriers to ALS research, Target ALS never asks for IP. All intellectual property resulting from work performed by researchers using our Core Resources is owned by those researchers.

As part of our strategy to provide “no-strings-attached” access to critical research tools, we are looking for collaborators to develop new animal models and to generate multi-omic datasets in mouse models to share with the community.  We have no active projects at this time. 

We offer annual funding calls in partnership with CROs in order to test candidate ALS therapeutics in standardized mouse models. Please watch our Funding Opportunities webpage and look for In Vivo Target Validation to apply for one of these opportunities.

Funded ALS research is ensured to adhere to ethical and non-biased standards through rigorous peer review processes, institutional review boards (IRBs), and oversight by ethics committees. These mechanisms assess research proposals, ensure participant welfare, and verify the integrity of the research design. Additionally, transparency, disclosure of potential conflicts of interest, and adherence to established research ethics guidelines contribute to maintaining ethical and unbiased standards in ALS research.